魏妥，研究员，博士生导师。博士毕业于中国科学院大学/国家纳米科学中心及法国艾克斯-马赛大学；2015-2021年先后于美国哈佛医学院波士顿儿童医院、麻省理工学院及美国德克萨斯大学西南医学中心从事博士后研究工作。2021年9月加入中国科学院动物研究所干细胞与生殖生物学国家重点实验室，成立纳米技术与药物递送研究组。研究组致力于研发安全、高效的纳米递送载体，应用于癌症、遗传类等重大疾病的治疗。已在Nat Nanotechnol., Nat Commun., Adv Mater.等国际知名杂志发表40余篇学术论文，被引7000余次，H指数为33（谷歌学术）。已申请国内外发明专利15项（已授权9项）。

课题组面向人类重大致死性疾病（如癌症、遗传类疾病等）治疗中的关键科学问题，运用化学、材料学、生物学、医学等多学科交叉，设计研发新型纳米递送技术平台，用以高效、特异性地递送小分子药物或生物大分子（包括RNA、蛋白质、基因编辑系统等），扩展并深化其生物医学领域的应用，主要研究方向：

1. 器官或细胞靶向型脂质纳米递送系统研发；
2. 新型基因编辑递送系统研发及基因编辑治疗研究；
3. 针对重大疾病（如肿瘤、代谢类疾病、遗传病等）的靶向基因治疗研究。

1. Luo Z, Lin Y, Meng Y, Li M, Ren H, Shi H, Cheng Q*, Wei T*. Spleen-Targeted mRNA Vaccine Doped with Manganese Adjuvant for Robust Anticancer Immunity In Vivo. ACS Nano. 2024, doi: 10.1021/acsnano.4c09902.
2. Fei Y, Yu X, Liu P, Ren H, Wei T*, Cheng Q*. Simplified Lipid Nanoparticles for Tissue- And Cell-Targeted mRNA Delivery Facilitate Precision Tumor Therapy in a Lung Metastasis Mouse Model. Adv Mater. 2024, doi: 10.1002/adma.202409812.
3. Lin Y, Cheng Q*, Wei T*. Surface Engineering of Lipid Nanoparticles: Targeted Nucleic Acid Delivery and Beyond. Biophys Rep. 2023, 9(5): 255-278. (Invited Review)
4. Wei T#, Sun Y#, Cheng Q#, Chatterjee S, Traylor Z, Johnson LT, Coquelin ML, Wang J, Torres MJ, Lian X, Wang X, Xiao Y, Hodges CA, Siegwart DJ. Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models. Nat Commun. 2023, 14(1):7322.
5. Zong Y, Lin Y, Wei T*, Cheng Q*. Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy. Adv Mater. 2023, https://doi.org/10.1002/adma.202303261.
6. Wei T*, Tao W*, Cheng Q*. Lipid nanoparticles for mRNA therapy: recent advances in targeted delivery. Life Medicine. 2022, https://doi.org/10.1093/lifemedi/lnac004.
7. Wei T#, Cheng Q#, Min YL, Olson EN, Siegwart DJ*. Systemic nanoparticle delivery of CRISPR/Cas9 ribonucleoproteins for effective tissue-specific genome editing. Nat Commun. 2020, 11(1):3232. (ESI高被引论文)
8. Cheng Q#, Wei T#, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ*. Selective ORgan Targeting (SORT) nanoparticles for tissue specific mRNA delivery and CRISPR/Cas gene editing. Nat Nanotechnol. 2020, 15(4):313. (ESI高被引论文)
9. Wei T, Cheng Q, Farbiak L, Anderson DG*, Langer R*, Siegwart DJ*. Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for in Vivo CRISPR/Cas-Based Genome Editing. ACS Nano. 2020, 14(8):9243.(Invited Review)
10. Liu J#, Wei T#, Zhao J, Huang Y, Deng H, Kumar A, Wang C, Liang Z, Ma X*, Liang X-J*. Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance. Biomaterials. 2016, 91:44.
11. Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang X-J*, Rocchi P, Peng L*. Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance. Proc Natl Acad Sci U S A. 2015, 112(10):2978.
12. Wei T#, Liu J#, Ma H, Cheng Q, Huang Y, Zhao J, Huo S, Xue X, Liang Z, Liang X-J*. Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo. Nano Lett. 2013, 13(6):2528.

（#共同第一作者, *通讯作者）