刘红美，博士，副研究员，硕士生导师。

教育经历

　　1999-2003年 兰州大学 生物学基地班 学士学位

　　2003-2008年 兰州大学 生物化学与分子生物学 博士学位

工作经历

　　2008年9月-2010年8月    Forschungszentrum Jülich, Germany    博士后

　　2010年10月-2019年2月    中国科学院动物研究所    助理研究员

　　2019年3月至今    中国科学院动物研究所    副研究员

1. DNA损伤与应答
2. 衰老与神经退行性疾病
3. 神经干细胞

　　2012 甘肃省技术发明一等奖

　　2012 甘肃省科学技术进步二等奖

　　2010 甘肃省药学发展奖一等奖

　　2008 Helmholtz-CSC奖学金

　　2008 求是研究生奖学金

　　2006 甘肃省李政道奖学金

　　2001 秦惠君与李政道中国大学生见习进修基金

　　国家自然科学基金 面上项目 2020-2024 主持

　　国家自然科学基金 青年科学基金项目 2013-2016 主持

　　中国科学院重点实验室开放课题 2018-2019 主持

　　科技部国家重点研发计划，2018-2022 项目骨干

　　国家自然科学基金委员会 国家重点项目 2018-2022 项目骨干

　　中国科学院A类战略性先导科技专项 2017-2021 项目骨干

　　（#第一作者或共同第一作者；*通讯作者）

1. Hongmei Liu#, Dongfang Jiang#, Fuwen Yao#, Tingting Li#, Bo Zhou#, Song Zhao, Keyan Yang, Haiping Feng, Jiaqi Shen, Jinglan Tang, Sijia Wang, Yu-Xin Zhang, Yun Wang, Qian Li, Yongliang Zhao, Caixia Guo*, Tieshan Tang*. Restoring carboxypeptidase E rescues BDNF maturation and neurogenesis in aged brains. Life Medicine, 2023, 2, 1-17.
2. 接欣雨，唐铁山，刘红美*。DNA双链断裂修复缺陷在神经退行性疾病发生中的作用。生物医学转化，2023, 4, 31- 41.
3. Dongfang Jiang#, Tingting Li#, Caixia Guo, Tieshan Tang*, Hongmei Liu*. Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration. Cell & Bioscience, 2023, 13: 10.
4. Song Zhao#, Haiping Feng#, Dongfang Jiang#, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu*, Caixia Guo*, Tieshan Tang*. ER Ca²⁺ overload activates the IRE1α signaling and promotes cell survival. Cell & Bioscience, 2023, 13: 123.
5. Chuanchao Zhang#, Bo Zhou#, *, Feng Gu#, Hongmei Liu#, Honglin Wu, Fuwen Yao, Hui Zheng, Hui Fu, Wei Chong, Shurui Cai, Min Huang, Xiaolu Ma, Zhifang Guo, Tingting Li, Wenyuan Deng, Meiwen Zheng, Qiao Ji, Yongliang Zhao, Yongjie Ma, Qi-En Wang, Tie-Shan Tang*, Caixia Guo*. Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation. Molecular Cell, 2022, 82, 1297-1312.
6. Keyan Yang#, Song Zhao#, Haiping Feng, Jiaqi Shen, Yuwei Chen, Si-Tong Wang, Si-jia Wang, Yu-xin Zhang, Yun Wang, Caixia Guo*, Hongmei Liu*, Tie-Shan Tang*. Ca²⁺ maintained by TMCO1 underlies corpus callosum development via ERK signaling. Cell Death & Disease, 2022, 13(8): 674.
7. Xiaoling Li*, Tie-Shan Tang, Caixia Guo*, Hongmei Liu*. Polymerases and DNA repair in neurons: implications in neuronal survival and neurodegenerative diseases. Frontiers in Cellular Neuroscience, 2022, 16:852002.
8. Tingting Li#, Hongmei Liu#, *, Dongfang Jiang, Keyan Yang, Jiaqi Shen, Haiping Feng, Sijia Wang, Yuxin Zhang, Yun Wang, Tie-Shan Tang*. BMP4 exerts anti-neurogenic effect via inducing Id3 during aging. Biomedicines, 2022, 10(5): 1147.
9. Hongmei Liu, Tieshan Tang, Caixia Guo*. Epigenetic profiles in polyglutamine disorders. Epigenomics, 2018, 10(1), 9-25.
10. 巩娟娟#, 刘红美#, 李巍*, 唐铁山*. RNA 结合蛋白RBM45参与DNA损伤应答。医学分子生物学杂志，2018, 6, 369-372.
11. Xiaolu Ma#, Hongmei Liu#, Jing Li#, Yihao Wang, Yue-He Ding, Hongyan Shen, Yeran Shen, Chenyi Sun, Min Huang, Yingfeng Tu, Yang Liu, Yongliang Zhao, Meng-Qiu Dong, Ping Xu, Tieshan Tang*, Caixia Guo. Poleta O-GlcNAcylation governs genome integrity during translesion DNA synthesis. Nature Communications, 2017, 8(1), 1941.
12. Yingfeng Tu#, Hongmei Liu#, Xuefei Zhu#, Hongyan Shen, Xiaolu Ma, Fengli Wang, Min Huang, Juanjuan Gong, Xiaoling Li, Yun Wang, Caixia Guo*, Tieshan Tang*. Ataxin-3 promotes genome integrity by stabilizing Chk1. Nucleic Acids Research, 2017, 45(8), 4532-4549.
13. Hongmei Liu#, Xiaoling Li#, Guozhu Ning#, Shu Zhu#, Xiaolu Ma, Xiuli Liu, Chunying Liu, Min Huang, Ina Schmitt, Ullrich Wuellner, Yamei Niu, Caixia Guo*, Qiang Wang*, Tieshan Tang*. The Machado-Joseph disease deubiquitinase ataxin-3 regulates the stability and apoptotic function of p53. PLoS Biology, 2016, 14(11), e2000733.
14. Susanner Aileen Funke#, Hongmei Liu#, Torsten Sehl, Dirk Bartnik, Oleksandr Brener, Luitgard Nagel-Steger, Katja Wiesehan, Dieter Willbold*. Identification and characterization of an abeta oligomer precipitating peptide that may be useful to explore gene therapeutic approaches to Alzheimer disease. Rejuvenation Research, 2012, 15(2), 144-147.
15. Hongmei Liu, Susanner Aileen Funke, Dieter Willbold*. Transport of Alzheimer disease amyloid-beta-binding D-amino acid peptides across an in vitro blood-brain barrier model. Rejuvenation Research, 2010, 13(2-3), 210-213.
16. Hongmei Liu, Yang Yang, Ruihua Xin, Xing Liu, Yiming Cao, Jingman Ni*, Rui Wang*. Differential cardiovascular effects of synthetic peptides derived from endomorphin-1 in anesthetized rats. Peptides, 2008, 29(6), 1048-1056.
17. Hongmei Liu#, Bangzhi Zhang#, Xuefeng Liu, Changlin Wang, Jingman Ni*, Rui Wang*. Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorganic Medicinal Chemistry, 2007, 15(4), 1694-1702.
18. Hongmei Liu, Xuefeng Liu, Jinlong Yao, Changlin Wang, Ye Yu, Rui Wang*. Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1. The Journal of Pharmacology and Experimental Therapeutics, 2006, 319(1), 308-316.
19. Jiuqiang Wang#, Shu Zhu#, Yihan Wang#, Fengli Wang#, Chaoqiang An#, Dongfang Jiang, Lijie Gao, Yingfeng Tu, Xuefei Zhu, Yun Wang, Hongmei Liu, Juanjuan Gong, Zhongshuai Sun, Xi Wang, Leimei Liu, Keyan Yang, Caixia Guo*, Tie-Shan Tang*. Miro2 supplies a platform for Parkin translocation to damaged mitochondria. Science Bulletin, 2019; 64:730-747.
20. Juanjuan Gong#, Min Huang#, Fengli Wang#, Xiaolu Ma, Hongmei Liu, Yingfeng Tu, Lingyu Xing, Xuefei Zhu, Hui Zheng, Junjie Fang, Xiaoling Li, Qiaochu Wang, Jiuqiang Wang, Zhongshuai Sun, Xi Wang, Yun Wang, Caixia Guo*, Tieshan Tang*. RBM45 competes with HDAC1 for binding to FUS in response to DNA damage. Nucleic Acids Research, 2017, 45(22), 12862-12876.
21. Xuefei Zhu#, Xiaolu Ma#, Yingfeng Tu#, Min Huang, Hongmei Liu, Fengli Wang, Juanjuan Gong, Jiuqiang Wang, Xiaoling Li, Qian Chen, Hongyan Shen, Shu Zhu, Yun Wang, Yang Liu, Caixia Guo*, Tieshan Tang. Parkin regulates translesion DNA synthesis in response to UV radiation. Oncotarget, 2017, 8(22), 36423-36437.
22. Xiaoling Li, Hongmei Liu, Paula L. Fischhaber*, Tieshan Tang*. Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance. Progress in Neurobiology, 2015, 132, 34-58.
23. Xiaoling Li, Fengqin Qu, Wenjuan Xie, Fengli Wang, Hongmei Liu, Shuhui Song, Tingting Chen, Yang Zhang, Shu Zhu, Yun Wang, Caixia Guo, Tieshan Tang*. Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal. Toxicological Sciences, 2014, 139(2), 452-465.
24. Lingna Lv, Fengli Wang, Xiaolu Ma, Yeran Yang, Zhifeng Wang, Hongmei Liu, Xiaoling Li, Zhenbo Liu, Ting Zhang, Min Huang, Errol C. Friedberg, Tieshan Tang, Caixia Guo*. Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. Nucleic Acids Research, 2013, 41(22), 10312-10322.
25. Changlin Wang, Xiang Wang, Ye Yu, Yun Cui, Hongmei Liu, Lu-hao Lai, Chao Guo, Jing Liu, Rui Wang*. Type 1 diabetes attenuates the modulatory effects of endomorphins on mouse colonic motility. Neuropeptides, 2008, 42(1), 69-77.
26. Changlin Wang, Jinlong Yao, Ye Yu, Xuan Shao, Yun Cui, Hongmei Liu, Luhao Lai, Rui Wang*. Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorganic Medicinal Chemistry, 2008, 16(12), 6415-6422.
27. Ye Yu, Xuan Shao, Changlin Wang, Hongmei Liu, Yun Cui, Yingzhe Fan, Jing Liu, Rui Wang. In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: evidence for the important role of proper spatial disposition of the third aromatic ring. Peptides, 2007, 28(4), 859-870.
28. Ye Yu, Xuan Shao, Yun Cui, Hongmei Liu, Changlin Wang, Yingzhe Fan, Jing Liu, Shouliang Dong, Yuxing Cui, Rui Wang. Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus. ChemMedChem, 2007, 2, 309-317.
29. Ye Yu, Changlin Wang, Yun Cui, Yingzhe Fan, Jing Liu, Xuan Shao, Hongmei Liu, Rui Wang*. C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats. Peptides, 2006, 27(1), 136-143.
30. Jing Liu#, Ye Yu#, Yingzhe Fan, Hui Chang, Hongmei Liu, Yun Cui, Qiang Chen, Rui Wang*. Cardiovascular effects of endomorphins in alloxan-induced diabetic rats. Peptides, 2005, 26(4), 607-614.

　　授权专利

1. 王锐，于烨，刘红美；“C末端改造的内吗啡肽2”，国家发明专利，授权号：ZL200710147468.3，授权日期，2011.12.7
2. 王锐，刘红美，刘雪峰;“组合化学修饰的内吗啡肽-1及其制备方法”，国家发明专利，授权号：ZL200610104541.4，授权日期，2010.12.8
3. 王锐，于烨，刘红美；“C末端改造的内吗啡肽-1”，国家发明专利，授权号：ZL200410073159.2，授权日期，2008.4.2