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姓　　名： 刘光慧
学　　科： 再生医学
电话/传真： +86-10-64807852 / 
电子邮件： ghliu@ioz.ac.cn
通讯地址： 北京市朝阳区大屯路甲3号院 中国科学院干细胞与再生医学创新研究院大楼膜生物学国家重点实验室 100101
更多信息： 衰老与再生研究组     

简历介绍：

刘光慧，博士，研究员，中国医学科学院学部委员，国际生理科学联合会生理学院会士，中国科学院动物研究所学术委员会副主任，膜生物学国家重点实验室副主任，北京干细胞与再生医学研究院副院长、学术委员会主任，国家自然科学基金委基础科学中心项目首席科学家，创新研究群体项目负责人，杰出青年基金项目获得者。

2002年毕业于北京大学医学部，获理学学士学位；2007年于中国科学院生物物理研究所获得理学博士学位；2007-2012年先后在美国斯克利普斯研究所（The Scripps Research Institute）和索尔克生物学研究所（Salk Institute for Biological Studies）从事博士后（Research Associate）研究；2012年加入中国科学院生物物理研究所，任研究员（PI）；2019年至今任中国科学院动物研究所研究员（PI）。

研究领域：

1. 人类衰老的遗传和表观遗传信息解码

结合灵长类动物模型、人干细胞、基因编辑、全基因组筛选、多组学分析及人工智能，研究人类衰老和老年疾病的遗传和表观遗传学基础，探索延缓衰老（如脑衰老和心血管衰老）和防治老年疾病（如神经退行性疾病和动脉粥样硬化症）的方法和手段，以期实现健康老龄化（healthy aging）的目标。

2. 基于干细胞技术的人类疾病机理研究和精准治疗

利用患者诱导性多能干细胞（iPSC）和体外创建的疾病胚胎干细胞（ESC），结合细胞、类器官定向分化和移植技术，在功能基因组水平研究人类疾病的分子机理及新型靶标；发展基于干细胞技术的药物筛选和评价体系；研发针对器官衰老和特定疾病靶标的候选药物（化合物）；推动干细胞和衰老相关技术的临床转化。

3. 新型基因编辑手段和基因治疗技术的发展和应用

以HDAdV、telHDAdV、TTALE和CRISPR/Cas9为基础，发展安全高效地编辑人类基因组的新方法，开发以去衰老和促再生为目标的干细胞和基因治疗新策略，为罕见疾病的基因修复、人类干细胞的遗传增强、以及衰老相关疾病的干预提供科学依据。

社会任职：

国际健康与寿命研究学会（AHLR）创会理事，中国细胞生物学学会衰老细胞生物学分会创会会长，中国老年学和老年医学学会抗衰老分会主任委员，《Life Medicine》主编，《Protein & Cell》副主编，《Cell Reports》编委，《PLOS Biology》编委，《Aging Cell》编委。

获奖及荣誉：

何梁何利基金科学与技术创新奖（2024），干细胞杰出贡献科学家（2024），北京市科学技术二等奖（第一位）（2023），中国科学十大进展（2023），中国生命科学十大进展（2023），国际生理科学联合会生理学院会士（2023），全国创新争先奖奖章（2023）、北京市有突出贡献的科学、技术、管理人才（2023），Elsevier中国高被引学者（2020-2023），中国医学科学院学部委员（2022），侨界贡献奖一等奖（2022），国家“十三五科技创新成就展”基础研究重大成果（2021），科学探索奖（2021），中华医学科技奖（2021），北京市杰出青年中关村奖（2021），中国科学十大进展（2020），中国生命科学十大进展（2020），中国科学院杰出科技成就奖（2020），国务院政府特殊津贴（2020），顾孝诚讲座奖（2019），药明康德生命化学研究奖（2019），中源协和生命医学创新突破奖（2019），中国青年科技奖特别奖（2018），谈家桢生命科学创新奖（2018），中国生命科学十大进展（2018），树兰医学青年奖（2017），首届老年医学杰出贡献奖（2017）。

承担科研项目情况：

代表论著：

  1. Yang Y, Lu X, Liu N, Ma S, Zhang H, Zhang Z, Yang K, Jiang M, Zheng Z, Qiao Y, Hu Q, Huang Y, Zhang Y, Xiong M, Liu L, Jiang X, Reddy P, Dong X, Xu F, Wang Q, Zhao Q, Lei J, Sun S, Jing Y, Li J, Cai Y, Fan Y, Yan K, Jing Y, Haghani A, Xing M, Zhu G, Song W, Horvath S, Esteban CR, Song M, Wang S, Zhao G, Li W, Belmonte JCB, Qu J*, Zhang W*, Liu GH*. Metformin Decelerates Aging Clock in Male Monkeys. Cell. 2024.187(22):6358-6378.
  2. Ma S, Ji Z, Zhang B, Geng L, Cai Y, Nie C, Li J, Zuo Y, Sun Y, Xu G, Liu B, Ai J, Liu F, Zhao L, Zhang J, Zhang H, Sun S, Huang H, Zhang Y, Ye Y, Fan Y, Zheng F, Hu J, Zhang B, Li J, Feng X, Zhang F, Zhuang Y, Li T, Yu Y, Bao Z, Pan S, Esteban CR, Liu Z, Deng H, Wen F, Song M, Wang S, Zhu G, Yang J, Jiang T, Song W, Belmonte JCI, Qu J*, Zhang W*, Gu Y*, Liu GH*. Spatial Transcriptomic Landscape Unveils Immunoglobin-associated Senescence as a Hallmark of Aging. Cell. 2024. doi: 10.1016/j.cell.2024.10.019.
  3. Li HY, Wang M, Jiang X, Jing Y, Wu Z, He Y, Yan K, Sun S, Ma S, Wang S, Belmonte JCB, Qu J*, Zhang W*, Wei T*, Liu GH*. CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver. Nucleic Acids Research. 2024.52(19):11481-11499.
  4. Wang Q, Wang X, Liu B, Ma S, Zhang F, Sun S, Jing Y, Fan Y, Ding Y, Xiong M, Li J, Zhai Q, Zheng Y, Liu C, Xu G, Yang J, Wang S, Ye J, Belmonte JCI, Qu J*, Liu GH*, Zhang W*. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland. Nature Aging. 2024. 4(3):396-413.
  5. Bi S, Jiang X, Ji Q, Wang Z, Ren J, Wang S, Yu Y, Wang R, Liu Z, Liu J, Hu J, Sun Q, Wu Z, Diao Z, Li J, Sun L, Belmonte JCI, Zhang W*, Liu GH*, Qu J*. The Sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA. Developmental Cell. 2024. S1534-5807(24)00107-2.
  6. Sun S, Li J, Wang S, Li J, Ren J, Bao Z, Sun L, Ma X, Zheng F, Ma S, Sun L, Wang M, Yu Y, Ma M, Wang Q, Chen Z, Ma H, Wang X, Wu Z, Zhang H, Yan K, Yang Y, Zhang Y, Zhang S, Lei J, Teng ZQ, Liu CM, Bai G, Wang YJ, Li J, Wang X, Zhao G, Jiang T, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. CHIT1-positive microglia drive motor neuron aging in the primate spinal cord. Nature. 2023. 624(7992):611-620.
  7. Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C,  Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell. 2023. 186(2):287-304.
  8. Jing Y, Jiang X, Ji Q, Wu Z, Wang W, Liu Z, Guillen-Garcia P, Eseban CR, Ready P, Horvath S, Li J, Geng L, Hu Q, Wang S, Belmonte JCI, Ren J*, Zhang W*, Qu J*, Liu GH*. Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation. Cell Stem Cell. 2023. 30(11):1452-1471.
  9. Cai Y, Xiong M, Xin Z, Liu C, Jie R，Yang X, Lei J, Li W, Liu F, Chu Q, Yin J, Ye Y, Liu D, Fan Y, Sun S, Zhao Q, Zhao L, Che S, Zheng Y, Yan H, Ma S, Wang S, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Decoding aging-dependent regenerative decline across tissues at single-cell resolution. Cell Stem Cell. 2023. 30(12):1674-1691.e8.
  10. Ye Y, Yang K, Liu H, Yu Y, Song M, Huang D, Lei J, Zhang Y, Liu Z, Chu Q, Fan Y, Zhang S, Jing Y, Esteban CR, Wang S, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B. Nature Aging. 2023. 3(10):1269-1287. (Cover story)
  11. Wu Z, Lu M, Liu D, Shi Y, Ren J, Wang S, Jing Y, Zhang S, Zhao Q, Li H, Yu Z, Liu Z, Bi S, Wei T, Yang Y, Xiao J, Belmonte JCI, Qu J*, Zhang W*, Ci W*, Liu GH*. M6A epitranscriptomic regulation of tissue homeostasis during primate aging. Nature Aging. 2023. 3(6):705-721. (Cover story)
  12. Li J, Xiong M, Fu XH, Fan Y, Dong C, Sun X, Zheng F, Wang SW, Liu L, Xu M, Wang C, Ping J, Che S, Wang Q, Yang K, Zuo Y, Lu X, Zheng Z, Lan T, Wang S, Ma S, Sun S, Zhang B, Chen CS, Cheng KY, Ye J, Qu J, Xue Y, Yang YG*, Zhang F*, Zhang W*, Liu GH*. Determining a Multimodal Aging Clock in a Cohort of Chinese Women. Med. 2023. 4(11):825-848.e13. (Cover story)
  13. Zhang H, Li J, Yu Y, Ren J, Liu Q, Bao Z, Sun S, Liu X, Ma S, Liu Z, Yan K, Wu Z,  Fan Y, Sun X, Zhang Y, Ji Q, Cheng F, Wei PH, Ma X, Zhang S, Xie Z, Niu Y, Wang WY, Han JD, Jiang T, Zhao G, Ji W, Belmonte JCI, Wang S*, Qu J*, Zhang W*, Liu GH*. Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging. Cell Reports. 2023. 42(6):112593.
  14. Sun S, Ma S, Cai Y, Wang S, Ren J, Yang Y, Ping J, Wang X, Zhang Y, Yan H, Li W, Esteban CR, Yu Y, Liu F, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A Single-cell Transcriptomic Atlas of Exercise-induced Anti-inflammatory and Geroprotective Effects across the Body. Innovation. 2023. 4(1):100380.
  15. Yan K, Ji Q, Zhao D, Li M, Sun X, Wang Z, Liu X, Liu Z, Li H, Ding Y, Wang S, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. SGF29 nuclear condensates reinforce cellular aging. Cell Discovery. 2023. 9(1):110.
  16. Sun G, Zheng Y, Fu X, Zhang W, Ren J, Ma S, Sun S, He X, Wang Q, Ji Z, Cheng F, Yan K, Liu Z, Belmonte JCI, Qu J*, Wang S*, Chai R*, Liu GH*. Single-Cell Transcriptomic Atlas of Mouse Cochlear Aging. Protein Cell. 2023. 14(3):180-201. (Cover story)
  17. Cheng F, Ji Q, Wang L, Wang CC, Liu GH*, Wang L*. Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H2O2 release. EMBO Reports. 2023. 24(8):e56439. (Cover story)
  18. Yang S, Liu C, Jiang M, Liu X, Geng L, Zhang Y, Sun S, Wang K, Yin J, Ma S, Wang S, Izpisua Belmonte JC, Zhang W*, Qu J*, Liu GH*. A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. Protein Cell. 2023. 15(2):98-120.
  19. Wang C, Yang K, Liu X, Wang S, Song M, Belmonte JCI, Qu J*, Liu GH*, Zhang W*. MAVS antagonizes human stem cell senescence as a mitochondrial stabilizer. Research. 2023. 6:0192.
  20. Jing Y, Zuo Y, Sun L, Yu ZR, Ma S, Hu H, Zhao Q, Huang D, Zhang W, Belmonte JCI, Yu Y*, Qu J*, Liu GH*, Wang S*. SESN1 is a FOXO3 effector that counteracts skeletal muscle aging in primates. Cell Proliferation. 2023. 56(5):e13455.
  21. Ma S, Wang S, Ye Y, Ren J, Chen R, Li W, Li J, Zhao L, Zhao Q, Sun G, Jing Y, Zuo Y, Xiong M, Yang Y, Wang Q, Lei J, Sun S, Long X, Song M, Yu S, Chan P, Wang J, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Heterochronic parabiosis induces systemic rejuvenation and stem cell revitalization across aged tissues. Cell Stem Cell. 2022. 29(6):990-1005.
  22. Liu Z, Ji Q, Ren J, Yan P, Wu Z, Wang S, Sun L, Wang Z, Li J, Sun G, Liang C, Sun R, Jiang X, Hu J, Ding Y, Wang Q, Bi S, Wei G, Cao G, Zhao G, Wang H, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Large-Scale Chromatin Reorganization Reactivates Placenta-Specific Genes that Drive Cellular Aging. Developmental Cell. 2022. 57(11):1347-1368.
  23. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*. Destabilizing heterochromatin by APOE mediates senescence. Nature Aging. 2022. 2(4):303-316.
  24. Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, Wang Z, Chen H, Xia K, Lai X, Wang Q, Yang K, Li W, Wu Z, Wang C, Yan H, Jiang X, Ji Z, Ma M, Long X, Wang S, Wang H, Sun H, Belmonte JCI, Qu J*, Xiang AP*, Liu GH*. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Research. 2022. 50(6):3323-3347.
  25. Kang W, Jin T, Zhang T, Ma S, Yan H, Liu Z, Ji Z, Cai Y, Wang S, Song M, Ren J, Hu B, Zhou Q, Zhang W*, Qu J*, Bao Y*, Liu GH*. Regeneration Roadmap: database resources for regenerative biology. Nucleic Acids Research. 2022. 50(D1):D1085-D1090.
  26. Yan H, Wang R, Ma S, Huang D, Wang S, Ren J, Lu C, Chen X, Zhang W*, Qu J*, Zhou Y*, Liu GH*. Lineage Landscape: A comprehensive database that records lineage commitment across species. Nucleic Acids Research. 2022.51(D1):D1061-D1066.
  27. Liu ZP, Li W, Geng L, Sun L, Wang Q, Yu Y, Yan P, Liang C, Ren J, Song M, Zhao Q, Lei J, Cai Y, Li J, Yan K, Wu Z, Chu Q, Li J, Wang S, Li C, Han JD, Hernandez-Benitez R, Shyh-Chang Ng, Izpisua Belmonte JC, Zhang WQ*, Qu J*, Liu GH*. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. Cell Discovery. 2022. 1;8(1):6.
  28. Shan H, Geng L, Jiang X, Song M, Wang J, Liu Z, Zhuo X, Wu Z, Ji Z, Wang S, Chan P, Qu J*, Zhang W*, Liu GH*. Large-Scale Chemical Screen Identifies Gallic Acid as a Geroprotector for Human Stem Cells. Protein Cell. 2022. 13(7):532-539.
  29. Jing Y, Zuo Y, Yu Y, Sun L, Yu ZR, Ma S, Zhao Q, Hu H, Li J, Liu L, Sun G, Li J, Belmonte JCI, Zhang W*, Wang S*, Qu J*, Liu GH*. Single-nucleus Profiling Unveils a Geroprotective Role of the FOXO3 in Primate Skeletal Muscle Aging. Protein Cell. 2022.14(7):497-512.
  30. Yuan B, Zhou X, Suzuki K, Ramos-Mandujano G, Wang M, Tehseen M, Cortés-Medina LV, Moresco JJ, Dunn S, Hernandez-Benitez R, Hishida T, Kim NY, Andijani MM, Bi C, Ku M, Takahashi Y, Xu J, Qiu J, Huang L, Benner C, Aizawa E, Qu J, Liu GH, Li Z, Yi F, Ghosheh Y, Shao C, Shokhirev M, Comoli P, Frassoni F, Yates JR 3rd, Fu XD, Esteban CR, Hamdan S, Li M, Izpisua Belmonte JC. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing. Nature Communications. 2022. 13(1):3646.
  31. Hishida T, Yamamoto M, Hishida-Nozaki Y, Shao C, Huang L, Wang C, Shojima K, Xue Y, Hang Y, Shokhirev M, Memczak S, Sahu SK, Hatanaka F, Ros RR, Maxwell MB, Chavez J, Shao Y, Liao HK, Martinez-Redondo P, Guillen-Guillen I, Hernandez-Benitez R, Esteban CR, Qu J, Holmes MC, Yi F, Hickey RD, Garcia PG, Delicado EN, Castells A, Campistol JM, Yu Y, Hargreaves DC, Asai A, Reddy P, Liu GH, Izpisua Belmonte JC. In vivo partial cellular reprogramming enhances liver plasticity and regeneration. Cell Reports. 2022. 39(4):110730.
  32. Wang W, Zheng Y, Sun S, Li W, Song M, Ji Q, Wu Z, Liu Z, Fan Y, Liu F, Li J, Esteban CR, Wang S, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Tang F*, Liu GH*. A Genome-wide CRISPR-Based Screen Identifies KAT7 as a Senescence Driver. Science Translational Medicine. 2021.13, Jan 6;13(575):eabd2655.
  33. Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S, Wang S, He Y, Esteban CR, Huang J, Yu N, Chan P, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A single-cell transcriptomic atlas of human skin aging. Developmental Cell. 2021. 56(3):383-397 (Cover story)
  34. Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W*, Qu J*, Liu GH*. Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2021. 31(2):187-205.
  35. Wang S, Yao X, Ma S, Ping Y, Fan Y, Sun S, He Z, Shi Y, Sun L, Xiao S, Song M, Cai J, Li J, Tang R, Zhao L, Wang C, Wang Q, Zhao L, Hu H, Liu X, Sun G, Chen L, Pan G, Chen H, Li Q, Zhang P, Xu Y, Feng H, Zhao GG, Wen T, Yang Y, Huang X, Li W, Liu Z, Wang H, Wu H, Hu B, Ren Y, Zhou Q, Qu J*, Zhang W*, Liu GH*, Bian XW*. A Single-cell Transcriptomic Landscape of the Human COVID-19 Lung. Nature Cell Biology. 2021. 23(12):1314-1328 (Leading contact)
  36. Zhang H, Li J, Ren J, Sun S, Ma S, Zhang W, Yu Y, Cai Y, Yan K, Li W, Hu B, Chan P, Zhao GG, Belmonte JCI, Zhou Q, Qu J*, Wang S*, Liu GH*. Single-nucleus transcriptomic landscape of primate hippocampal aging. Protein Cell. 2021. 12(9):695-716. (Cover story)
  37. Aging Atlas Consortium, Zhang W*, Jing Qu*, Bao Y*, Liu GH*. Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Research. 2021. 8;49(D1):D825-D830.
  38. Li H, Wei X, Zhou L, Zhang W, Wang C, Guo Y, Li D, Chen J, Liu T, Zhang Y, Ma S, Wang C, Tan F, Xu J, Liu Y, Yuan Y, Chen L, Wang Q, Qu J, Shen Y, Liu S, Fan G, Liu L, Liu X, Hou Y, Liu GH*, Gu Y*, Xu X*. Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis. Protein Cell.  2021. 12(1):57-66.
  39. Li CJ, Xiao Y, Sun YC, He WZ, Liu L, Huang M, He C, Huang M, Chen KC, Hou J, Feng X, Su T, Guo Q, Huang Y, Peng H, Yang M, Liu GH, Luo XH. Senescent immune cells release Grancalcin to promote skeletal aging. Cell Metabolism. 2021.33(10):1957-1973.
  40. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JCI*, Jing Qu*, Tang F*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180(3):585-600. (Cover story)
  41. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI*, Zhang W*, Qu J*, Liu GH*. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020. 180(5):984-1001.
  42. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research. 2020. 10;1-18.
  43. Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W*, Sun Q*, Qu J*, Liu GH*. Genome-wide R-loop landscapes during cell differentiation and reprogramming. Cell Reports. 2020. 32(1):107870
  44. Wang F, Zhang W, Yang Q, Kang Y, Fan Y, Wei J, Liu Z, Dai S, Li H, Li Z, Xu L, Chu C, Qu J, Si C, Ji W*, Liu GH*, Long C*, Niu Y*. Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing. Protein Cell. 2020. 11(11):809-824. (Cover story)
  45. Zheng Y, Liu X, Le W, Xie L, Li H, Wen W, Wang S, Ma S, Huang Z, Ye J, Shi W, Ye Y, Liu Z, Song M, Zhang W, Belmonte JCI, Xiao C, Qu J*, Wang H*, Liu GH*, Su W*. A human circulating immune cell landscape in aging and COVID-19. Protein Cell. 2020. 192:111357.
  46. Wang S, Min Z, Ji Q, Geng L, Su Y, Liu Z, Hu H, Wang L, Zhang W, Suzuiki K, Huang Y，Zhang P, Tang T, Qu J*, Yu Y*, Liu GH*, Qiao J*. Rescue of Premature Aging Defects in Cockayne Syndrome Stem Cells by CRISPR/Cas9-Mediated Gene Correction. Protein Cell. 2020. 11(1):1-22.
  47. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Izpisua Belmonte JC, Qu J*, Tang F*, Liu GH*. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell Stem Cell. 2019. 24(3), 447-461. (Cover story)
  48. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Izpisua Belmonte JC, Chan P, Qu J*, Liu GH*. Stabilizing Heterochromatin by DGCR8 Alleviates Senescence and Osteoarthritis. Nature Communications. 2019.10(1):3329.
  49. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J*, Tang F*, Liu GH*. Upregulation of FOXD1 by YAP Alleviates Senescence and Osteoarthritis. PLoS Biology. 2019. 17(4):e3000201.
  50. Ling C, Liu Z, Song M, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu L, Chu Q, Izpisua Belmonte JC, Wang Z, Qu J*, Yuan Y*, Liu GH*. Modeling CADASIL Vascular Pathologies with Patient-Derived Induced Pluripotent Stem Cells. Protein Cell. 2019. 10(4):249-271.
  51. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J*, Tang F*, Liu GH*. Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. Cell Reports. 2019. 26(13):3643-3656.
  52. Geng L, Liu Z, Zhang W*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH*. Chemical Screen Identifies a Geroprotective Role of Quercetin in Premature Aging. Protein Cell. 2019. 10(6):417-435.
  53. Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*. SIRT6 Deficiency Results in Developmental Retardation in Cynomolgus Monkeys. Nature. 2018. 560(7720):661-665 (Leading contact)
  54. Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J*, Tang F*, Liu GH*. ATF6 Safeguards Organelle Homeostasis and Cellular Aging in Human Mesenchymal Stem Cells. Cell Discovery. 2018. Jan 5;4:2.
  55. Fang J, Yang J, Wu X, Zhang G, Li T, Zhang H, Wang CC, Liu GH*, Wang L*. Metformin Alleviates Human Cellular Aging by Upregulating the ER Peroxidase GPx7. Aging Cell. 2018.17(4):e12765.
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综述或观点：

  1. Metabolic heterogeneity in humans. Cell. 2024. 187(15):3821-3823. (Leading Edge Voices)
  2. Roles of chromatin and genomic instabilities in cellular senescence and their relevance to ageing and related diseases. Nature Reviews Molecular Cell Biology. 2024. doi:10.1038/s41580-024-00775-3.
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  4. Targeting aging and age-related diseases with vaccines. Nature Aging. 2024.4(4):464-482.
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  7. Multimodal omics approaches to aging and age-related diseases. Phenomics. 2024. 4(1):56-71.
  8. The Aging Biomarker Consortium represents a new era for aging research in China. Nature Medicine. 2023. 29(9):2162-2165.
  9. Endogenous retroviruses in mammalian development and health. Trends in Microbiology. 2023. S0966-842X(23)00267-6.
  10. Acting on ethics and governance of aging research. Trends in Molecular Medicine. 2023. 29(6):419-421.
  11. Decoding Aging Hallmarks at the Single-Cell Level. Annual Review of Biomedical Data Science. 2023. 10:6:129-152.
  12. Biomarkers of aging. Science China Life Science. 2023. 66(5):893-1066. (Cover story)
  13. Q&A with Guang-Hui Liu. Cell Reports. 2023. 42(8):112862.
  14. Deciphering RNA m6A regulation in aging: Perspectives on current advances and future directions. Aging Cell. 2023. 22(10):e13972.
  15. A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine. 2023.2(3): lnad017.
  16. Hepatocyte reprogramming in liver regeneration: biological mechanisms and applications. The FEBS Journal. 2023. 290(24):5674-5688.
  17. Glutathione restoration: a sword to combat skeletal muscle stem cell aging. Life Metabolism. 2023. 2(3):load012.
  18. A narrative review of organoids for investigating organ aging: opportunities and challenges. Journal of Bio-X Research. 2023. 6(1):p 3-14. (Cover story)
  19. Fecal microbiota transplantation: a new strategy to delay aging. hLife. 2023.1(1):8-11.
  20. Longevity secret - a pluripotent superpower. Cell Metabolism. 2022. 34(6):803-804.
  21. Voicing the story behind the cover. Developmental Cell. 2022. 57(24):2679-2682.
  22. A Stem Cell Aging Framework, from Mechanisms to Interventions. Cell Reports. 2022. 41(3):111451.
  23. The landscape of aging. Science China Life Science. 2022 2:1-101.
  24. Opening up the black box of human cell plasticity. Innovation. 2022 3(5):100276.
  25. Epigenetic regulation of aging: implications for interventions of aging and diseases. Signal Transduction and Targeted Therapy. 2022. 7(1):374.
  26. Genetic Enhancement: an Avenue to Combat Aging-related Diseases. Life Medicine. 2022.1(3): 307–318.
  27. Emerging role of RNA m6A modification in aging regulation. Current Medicine. 2022. 1(8).
  28. Potential Approaches for Intervening Aging. National Science Open. 2022.1(2): 20220021.
  29. Deciphering aging at three-dimensional genomic resolution. Cell Insight. 2022. 1(3):100034.
  30. Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors. Stem Cells Translational Medicine.2022. 11(3):231-238.
  31. Mitochondrial sirtuins, metabolism, and aging. J Genet Genomics. 2022. 49(4):287-298.
  32. The Aging Epigenome and its Rejuvenation. Nature Reviews Molecular Cell Biology. 2020. 21(3):137-150.
  33. Engineering Tissues and Organs: The Road to the Clinic. Cell. 2020. 181(1):22-23. (Leading Edge Voices)
  34. Single-Cell “OMICS” in Aging: A Young Growing Field. Nature Metabolism. 2020. 2(4): 293-302.
  35. A Beta-Galactosidase Kiss of Death for Senescent Cells. Cell Research. 2020. 30(7):556-557.
  36. Treating Osteoarthritis via Gene Therapy with Rejuvenation Factors. Gene Therapy. 2020. 27(7-8):309-311.
  37. Protein Quality Control of Cell Stemness. Cell Regeneration. 2020. 12;9(1):22.
  38. Age-Related Cardiopathies Gene Editing. Aging. 2019. 11(5):1327-1328.
  39. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018. 123(7):773-786.
  40. Regulation of Stem Cell Aging by Metabolism and Epigenetic Factors. Cell Metabolism. 2017. 26(3):460-474.

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